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Gene Expression Literature Summary
Assay
Age
In situ RNA (whole mount)
11 DPC

12 matching records from 12 references.

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Gli3  GLI-Kruppel family member GLI3   (Synonyms: Bph, brachyphalangy)
Results  Reference
1J:283343 Bastida MF, Perez-Gomez R, Trofka A, Zhu J, Rada-Iglesias A, Sheth R, Stadler HS, Mackem S, Ros MA, The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13. Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1090-1096
1*J:45211 Buscher D, Ruther U, Expression profile of Gli family members and Shh in normal and mutant mouse limb development. Dev Dyn. 1998 Jan;211(1):88-96
1J:109528 Capellini TD, Di Giacomo G, Salsi V, Brendolan A, Ferretti E, Srivastava D, Zappavigna V, Selleri L, Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development. 2006 Jun;133(11):2263-73
1*J:186282 Du J, Fan Z, Ma X, Wu Y, Liu S, Gao Y, Wang J, Shen Y, Fan M, Wang S, Different expression patterns of Gli1-3 in mouse embryonic maxillofacial development. Acta Histochem. 2012 Oct;114(6):620-5
1J:232111 Emechebe U, Kumar P P, Rozenberg JM, Moore B, Firment A, Mirshahi T, Moon AM, T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number. Elife. 2016;5:e07897
1J:112460 Hatsell SJ, Cowin P, Gli3-mediated repression of Hedgehog targets is required for normal mammary development. Development. 2006 Sep;133(18):3661-70
1J:125087 Hill P, Wang B, Ruther U, The molecular basis of Pallister Hall associated polydactyly. Hum Mol Genet. 2007 Sep 1;16(17):2089-96
1J:69771 Lewis PM, Dunn MP, McMahon JA, Logan M, Martin JF, St-Jacques B, McMahon AP, Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell. 2001 Jun 1;105(5):599-612
1*J:213418 Li D, Sakuma R, Vakili NA, Mo R, Puviindran V, Deimling S, Zhang X, Hopyan S, Hui CC, Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling. Dev Cell. 2014 Apr 28;29(2):233-40
1*J:38196 Masuya H, Sagai T, Moriwaki K, Shiroishi T, Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouse. Dev Biol. 1997 Feb 1;182(1):42-51
1J:109476 Veltmaat JM, Relaix F, Le LT, Kratochwil K, Sala FG, van Veelen W, Rice R, Spencer-Dene B, Mailleux AA, Rice DP, Thiery JP, Bellusci S, Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development. 2006 Jun;133(12):2325-35
1J:149477 Zhang Z, Verheyden JM, Hassell JA, Sun X, FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev Cell. 2009 Apr;16(4):607-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory